Ibuprofen side effects dry mouth7/25/2023 ![]() 3 - 5 Use of currently available treatments, including tear and saliva substitutes, provides transient relief at best and often fails to prevent complications. In addition to significant discomfort from dryness, untreated dry mouth and dry eyes may also lead to complications, including stomatopyrosis (burning mouth), oral ulcers, malnutrition, weight loss, oral candidiasis, bacterial sialadenitis, sleep disruption, accelerated dental caries, periodontal disease, corneal ulceration or perforation, and bacterial conjunctivitis. ![]() Morbidity from salivary and lacrimal gland hypofunction results from alteration of mucosal and ocular surfaces and breakdown of the normal host barriers to infection. Over time, progressive infiltration of lacrimal and salivary glands by mononuclear cells leads to diminished secretions, with resultant xerostomia (dry mouth) and xerophthalmia (dry eyes) being the most prevalent symptoms. SJÖGREN SYNDROME (SS) is a chronic, autoimmune, rheumatic disorder characterized by lymphocyte-mediated destruction of exocrine glands and internal organ involvement that occur in association with autoantibody production or as a complication of a preexisting connective tissue disorder. The most common adverse effect was sweating, and no serious drug-related adverse experiences were reported.Ĭonclusion Administration of 5-mg pilocarpine tablets 4 times daily (20 mg/d) was well tolerated and produced significant improvement in symptoms of dry mouth and dry eyes and other xeroses in patients with SS. ![]() Salivary flow was significantly increased 2- to 3-fold ( P<.001) after administration of the first dose and was maintained throughout the 12-week study. Results A significantly greater proportion of patients in the 5-mg pilocarpine group showed improvement compared with the placebo group ( P≤.01) in global assessments of dry mouth, dry eyes, and other symptoms of dryness ( P≤.05). Whole-mouth salivary flow rates were measured. Symptoms were assessed by questionnaires with visual analog scales or categorical checkboxes. Methods After providing written informed consent, 373 patients with primary or secondary SS and clinically significant dry mouth and dry eyes were randomized to receive 2.5-mg pilocarpine, 5-mg pilocarpine, or placebo tablets 4 times daily for 12 weeks. ![]() Objective To assess the safety and efficacy of pilocarpine (Salagen) tablets as symptomatic treatment for dry mouth and dry eyes caused by SS in a multicenter, double-blind, placebo-controlled trial. Although pilocarpine hydrochloride tablets are currently indicated for the treatment of radiation-induced xerostomia, their effects on dry mouth or dry eyes in patients with SS are unclear. This leads to diminished secretions, with resultant symptoms of xerostomia and xerophthalmia. Shared Decision Making and Communicationīackground Patients with Sjögren syndrome (SS) experience slowly progressive infiltration of lacrimal and salivary glands by mononuclear cells.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.
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